Genetic heterogeneity of HER2/Neu in breast carcinoma: a meta analysis
نویسندگان
چکیده
Both immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) are accepted methods fordetermining clinical HER2 (or ERBB2) status. However, the reliability of IHC and FISH is questionable. The genetic heterogeneity (GH) of breast carcinoma is a major cause that makes its diagnosis and treatment far from being optimal. To clarify the impact of FISH and IHC testing on HER2 GH, a meta-analysis was performed in this study. A total of eight studies with 11478 patients retrieved from PubMed and Embase were included. A random-effects meta-analysis of all studies suggested GH was existed in FISH equivocal test (OR=30.98, 95% CI 21.19-45.30) and IHC equivocal test (OR=1.56, 95% CI 1.40-1.74), respectively. Further analysis indicated that the significant differences presented between GH and different HER2 expression by FISH test (x2=864.23, P<0.001), and between GH and different HER2 expression using IHC test (x2=206.52, P<0.001), respectively. Networks revealed that HER2 regulates different downstream proteins to coordinate numerous processes. Our results suggested that GH of HER2 differentially presented in a subset of HER2 amplified breast carcinomas, especially in cases with HER2 expression (FISH equivocal and IHC equivocal). There is a substantial difference in the frequency of GH among different ethnicities. HER2 GH is more likely to exist in FISH equivocal test than IHC equivocal test, and it is more convenient to document GH status by FISH test. We suggest FISH as the primary HER2 testing modality with breast carcinomas who are candidate for HER2 targeted therapy. FISH equivocal test is necessary to be further standardized in order to better define HER2 status and it is important to incorporate GH into the management of breast patients.
منابع مشابه
Cytoplasmic Her2/neu immunohistochemical staining in breast cancer; From a molecular point of view
متن کامل
بررسی هیستوپاتولوژی و مارکرهای بیولوژی در زنان مبتلا به سرطان پستان قبل از یائسگی (زیر 40 سال) و پس از یائسگی (بالای 60 سال) در بیمارستان رسول اکرم(ص) و آتیه
Background & Aim: Breast carcinoma is the most common malignant tumor and the leading cause of carcinoma death in women.One of the factors which have been proposed in prognosis and treatment of breast carcinoma is hormonal status and hormonal receptors. In this study, we investigated histopathology(prognostic factors) and biologic markers(estrogen receptor ER, progesterone receptor PR, P53...
متن کاملCorrelation Of Her-2/Neu And Tp53 Expressions With Clinicopathologic Characteristics In Infiltrative Ductal Breast Carcinomas
Objective: To review Her-2/neu and Tp53 status and their correlation with all other prognostic clinicopathologic features of infiltrative ductal breast carcinomas. Materials and Methods: This cross sectional study was performed on 139 patients with infiltrative ductal breast carcinoma who were diagnosed between May 2000 and March 2006 at the surgery and pathology departments of Alzahra Hosp...
متن کاملImmunohistochemical Study of HER2/neu Overexpression in Adenoid Cystic Carcinoma of Salivary Glands
Background and Objectives: Adenoid cystic carcinoma (ACC), the most common malignant tumor of submandibular and minor salivary glands, is characterized by a high rate of local recurrence and distant hematogenous metastasis and tendency to invade peripheral nerves. In spite of radiotherapy and surgical treatment, the long-term prognosis is dismal. Today, many studies are being conducted using...
متن کاملEvaluation of HER2/neu Expression in High-Grade Endometrial Carcinoma and Its Clinicopathological Correlation
Background & Objective: Endometrial carcinoma (EC) has been traditionally classified into two distinct categories of low-grade and high-grade. Type I (low grade) EC, which constitutes the majority of cases, is linked to estrogen-related molecular pathways. But type II (high-grade) EC accounts for 10-20% of cases and behaves in an aggressive way. Pathologic and biological featur...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2017